bile canaliculi lined by

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    Epub 2006 May 10. Bile Canaliculi (#1 and #2) - bile is secreted into 1 to 2 µm diameter tubes formed by adjacent hepatocytes that drain into bile ductules at the portal triads. Author information: (1)Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, USA. Epub 2005 Feb 16. A. HHS NLM Biliary anatomy and flow. Please enable it to take advantage of the complete set of features! 6 The gallbladder is made up of the larger fundus toward the apex and the infundibulum, or neck, which empties into the cystic duct. Intracellular sites involved in the biogenesis of bile canaliculi in hepatic cells. The plasma membrane of hepatocytes can be divided in sinusoidal, lateral and apical membrane, each with functionally and structurally distinct features. 3) which are endothelial-lined channels that run between the cords of hepatocytes, arranged radially from the central vein. Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway. Casey CA, Bhat G, Holzapfel MS, Petrosyan A. sinusoids (Fig. Clipboard, Search History, and several other advanced features are temporarily unavailable. These ductules lead away from the central vein, and toward the region of the triad. preformed and assembled in the intracellular microvilli-. A liver sinusoid is a type of capillary known as a sinusoidal capillary, discontinuous capillary or sinusoid, that is similar to a fenestrated capillary, having discontinuous endothelium that serves as a location for mixing of the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.. 2006 Feb;323(2):233-43. doi: 10.1007/s00441-005-0067-2. 1997 Dec 1;39(5):406-12. doi: 10.1002/(SICI)1097-0029(19971201)39:5<406::AID-JEMT3>3.0.CO;2-E. Stewart DJ, Short KK, Maniaci BN, Burkhead JL. 2001;8(1):20-6. doi: 10.1007/s005340170047. USA.gov.  |  Biliary passages begin as tiny bile canaliculi formed by hepatocytes. Epub 2011 Jan 10. Decribe the path of bile to the main hepatic ducts. Mature bile canaliculi appeared between adjacent cells 48 hours after the release of the nocodazole block. vesicle fusion. Fu D, Wakabayashi Y, Ido Y, Lippincott-Schwartz J, Arias IM.  |  • Bile is excreted from hepatocytes into bile canaliculi canals of Hering bile ducts The canaliculi function to secrete and concentrate components of the bile and to transport the bile out of the interior of the hepatic parenchymal tissue to the epithelium-lined bile ducts. The columnar mucosa is arranged in folds over the lamina propria, allowing expansion. The formation of the bile canaliculi was monitored by using immunofluorescence microscopy, confocal laser scanning microscopy, and immunoelectron microscopy. Longitudinal Section - are seen as darker staining lines between adjacent hepatocytes. These results are also discussed in terms of the bile canaliculus. Contents empty into canals of Hering lined by cholangiocytes. • Hepatocytes arranged in thin plates/cords (1-2 cells thick). Primary hepatocytes self-assemble into spheroids that possess tight junctions and microvilli-lined channels. Bile ductules have a central lumen lined by a single layer of cuboidal epithelial cells. Please enable it to take advantage of the complete set of features! Microsc Res Tech. Bile ductules have a basal lamina. It ; Blood sinusoids are lined by the endothelial cells. 10.1002/(SICI)1097-0029(19971201)39:5<406::AID-JEMT3>3.0.CO;2-E. How to induce non-polarized cells of hepatic origin to express typical hepatocyte polarity: generation of new highly polarized cell models with developed and functional bile canaliculi. The intrahepatic ducts, cystic duct, and the common bile duct are lined by a tall columnar epithelium. Fu D, Wakabayashi Y, Lippincott-Schwartz J, Arias IM. Epub 2005 Oct 18. USA.gov. At the ends of the canaliculi, bile flows into bile ducts, which are true ducts lined with epithelial cells. They penetrate the portal space and connect with the interlobular bile duct. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. They were round, vesicle-like structures lined with microvilli and sealed by tight junctions and desmosomes. J Clin Invest.  |  Identify excretory ducts, interlobular ducts, intercalated ducts, acinar and centroacinar cells in the pancreas. Epub 2016 May 12. The biliary system consists of a gallbladder, cystic duct, common bile duct (CBD), hepatic ducts, segmental, septal, and interlobular bile ducts, bile ductules, and hepatic canaliculi. Bile canaliculus (plural:bile canaliculi; also called bile capillaries) is a thin tube that collects bile secreted by hepatocytes. J Cell Sci. The bile canaliculi empty into a series of progressively larger bile ductules and ducts, which eventually become common hepatic duct. Developing hepatic cords were lined by a laminin–positive basement membrane and by CD31-positive sinusoid endothelial cells (Figure 4E and 4F). • Sinusoidal spaces lined by endothelial cells and filled with blood, Kupffer cells and stellate cells. NIH C. A 50-year-old woman presents to the family medicine clinic. Herrema H, Czajkowska D, Théard D, van der Wouden JM, Kalicharan D, Zolghadr B, Hoekstra D, van Ijzendoorn SC. These microvilli -lined structures progress into ductules, interlobular bile ducts, and larger hepatic ducts. Epub 2010 Sep 7. Antibodies to alpha-fodrin and villin were used. The bile canaliculus lined by hepatocytes meets the ductule, first lined by hepatocytes and ductal epithelium, then lined only by ductal cells. Rigalli JP, Perdomo VG, Ciriaci N, Francés DE, Ronco MT, Bataille AM, Ghanem CI, Ruiz ML, Manautou JE, Catania VA. Toxicol Appl Pharmacol. Sepsis and cholestasis: basic findings in the sinusoid and bile canaliculus. This site needs JavaScript to work properly. We hypothesized that polarity develops gradually and that the channels structurally and … Zaal KJ, Kok JW, Sormunen R, Eskelinen S, Hoekstra D. Microsc Res Tech. This site needs JavaScript to work properly. Liver Sinusoids: What is the source of blood entering the sinusoids: ... Bile Canaliculi (tiny intercellular channels) -between hepatocytes-have tight junctions Bile Ducts - lined with a simple cuboidal epithelium. NIH Which description is true of the bile canaliculi? Bile, made by hepatocytes from the breakdown of Hemoglobin and other materials, flows from the hepatocytes into tiny channels between them called Bile Canaliculi. Failure of the canaliculi to form and function properly can lead to biliary stasis or release of bile components into the bloodstream, both potentially life-threatening situations. As the bile canaliculi join near the periphery of the lobules, they form into larger canals (also known as the Canals of Hering). These sites probably represent areas destined to develop into bile canaliculi. Proc Natl Acad Sci U S A. Best seen by electron microscopy, they are small intercellular channels formed by groove-like invaginations of adjacent hepatocytes. Ultrastructural aspects of the human primary liver cancer. ... Liver Hepatocytes - radiate out from the central vein organized in hepatic cords Hepatic Cords are lined with endothelial cells Spaces between hepatocytes are called Hepatic Sinusoids Von Kupffer Cells - fixed macrophages found in sinuoids Bile Canaliculi - … The bile canaliculi of human hepatocytes may be preformed and assembled in the intracellular, microvilli‐lined vesicles, then vectorially transported to the cell surface, where they form the bile canaliculi through vesicles fusion. Outside the porta hepatis, the main hepatic duct joins the cystic duct from the gallbladder to form the common bile duct, which drains into the duodenum. These Bile Canaliculi are not distinct vessels with walls of their own, but are channels that are lined by …  |  The gallbladder stores bile excreted from the liver. Bile ductules from portal triads course through the liver and connect to form increasingly larger caliber structures, bile ducts, that are lined by short to tall columnar epithelium. A network of bile canaliculi is located within each plate of hepatocytes, but these are far too small to be seen at this magnification. canaliculi of human hepatoma cell lines might be. Typically, mature bile canaliculi were delineated by a subplasmalemmal filamentous meshwork of fodrin and actin, resembling a terminal web of enterocytes. doi: 10.1242/jcs.231753. The flow of bile is opposite to that of the blood and the canals of Hering are capable of contracting and assisting this flow towards the portal canal. They were usually seen between two juxtaposed cells, and often several cells contributed to their formation. These sinusoids are lined by specialized endothelial cells, Kupffer’s cells (phagocytic cells) and fatstorage cells (Ito cells) and are separated by plates ofliver cells (hepatocytes). Are bordered directly by endothelial cells b. The results show that (i) bile canaliculi are formed de novo between two or more juxtaposed cells; (ii) canalicular-formation is accompanied by a distinct accumulation of the membrane skeletal and microvillar proteins fodrin, actin and villin at the apical surfaces of the cells, suggesting that they play an important role in bile canaliculus morphogenesis, and that (iii) apical membrane differentiation in the cells contributing to the formation of a single canaliculus is an asymmetric process. HHS Bile canaliculus formation in cultured HEPG2 cells. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Vassy J, Irinopoulou T, Beil M, Rigaut JP. The bile canaliculi drain through short bile ductules (cholangioles), partially lined by cuboidal epithelial cells, to bile ducts, lined with simple cuboidal epithelium, which course along with branches of the portal vein and hepatic artery in portal tracts. -lined by fenestrated (leaky) endothelial cells -allows plasma to pour out of them & bathes the hepatocytes with fluid. The cholangioles are lined with squamous epithelium and as they begin, there may be squamous epithelium on one side and a parenchymal cell on the other. 2016 Aug 1;304:90-8. doi: 10.1016/j.taap.2016.05.007. Confocal laser scanning microscopy showed accumulations of actin, villin and fodrin at the cell membranes 8 to 12 hours after the release of the nocodazole block.  |  Bile canaliculi (histological slide) These canals are lined by both hepatocytes and cuboidal cholangiocytes. The potential space that lies between the sinusoids and hepatocytes is the space of Disses. Rho kinase, myosin-II, and p42/44 MAPK control extracellular matrix-mediated apical bile canalicular lumen morphogenesis in HepG2 cells. Study of Ethanol-Induced Golgi Disorganization Reveals the Potential Mechanism of Alcohol-Impaired N-Glycosylation. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. We also used the 9B2 monoclonal antibody, previously shown to be specific for the human bile canalicular domain, to study formation of bile canaliculi in these human hepatoma cell lines. Bile canaliculi form a network between the hepatocytes. Actin was visualized with rhodamine phalloidin. Bile is produced exclusively by hepatocytes and secreted into the bile canaliculi, which are gutter-like structures between two or three adja-cent hepatocytes in the hepatocytic plates (11). Development and maintenance of bile canaliculi in vitro and in vivo. Biliary passages start with tiny bile canaliculi between hepatocytes. In the sinusoids, the blood flows centrally towards the hepatic veins, whereas bile, secreted by the hepatocytes, flows in the canaliculi in the opposite The bile ductule is lined by simple cuboidal to columnar epithelium and drains exocrine secretions of hepatocytes from the liver. Bile Duct junction 2. Clipboard, Search History, and several other advanced features are temporarily unavailable. This article summarizes what is known about how the functional components of the canaliculus develop and the directions that current experimental approaches are leading in analyzing this process. A bile canaliculus (BC) is formed from the plasma membranes of adjacent hepatocytes sealed off by tight junctions (J). Abu-Absi SF (1), Friend JR, Hansen LK, Hu WS. The apical surfaces of hepatocytes are specialized to form the boundaries of the bile canaliculi. Experimental analysis of canaliculus development and function has been undertaken in a number of experimental systems, ranging in complexity from intact animals to isolated hepatocyte cell cultures. The bile is secreted by hepatocytes into the bile canaliculi. The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2). They were round, vesicle-like structures lined with microvilli and sealed by tight junctions and desmosomes. Biliary system. doi: 10.1371/journal.pone.0119502. ® 1-2 Bile ductules - same size. COVID-19 is an emerging, rapidly evolving situation. They were usually seen between two juxtaposed cells, and often several cells contributed to their formation. Alcohol Clin Exp Res. The canaliculi function to secrete and concentrate components of the bile and to transport the bile out of the interior of the hepatic parenchymal tissue to the epithelium-lined bile ducts. COVID-19 is an emerging, rapidly evolving situation. Which of the following is true regarding peristalsis in the digestive system? Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models. cell surface where they formed bile canaliculi through. The Canals of Hering empty into bile ductules, located within portal triads. 2016 Dec;40(12):2573-2590. doi: 10.1111/acer.13247. Smith CR, Oshio C, Miyairi M, Katz H, Phillips MJ. I. 2011 Jan 25;108(4):1403-8. doi: 10.1073/pnas.1018376108. Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis. NLM The morphogenesis and the polarization of hepatocytes is still poorly known. doi: 10.1002/(SICI)1097-0029(19971201)39:5<406::AID-JEMT3>3.0.CO;2-E. Peng X, Grosse B, Le Tiec B, Nicolas V, Delagebeaudeuf C, Bedda T, Decaens C, Cassio D. Cell Tissue Res. Actin and villin were also found in microvillar cores. Experimental design: Rigalli JP, Ciriaci N, Arias A, Ceballos MP, Villanueva SS, Luquita MG, Mottino AD, Ghanem CI, Catania VA, Ruiz ML. Spatial distribution of cytoskeleton intermediate filaments during fetal rat hepatocyte differentiation. The apex of the hepatocytes contains microvilli (Mv) and is exposed to the space of Disse (D) which in turn is incompletely lined by the sinusoidal endothelium (S). Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Coordination of the contractile activity of bile canaliculi. 2019 Oct 9;132(19):jcs231753. 2010 Oct 1;123(Pt 19):3294-302. doi: 10.1242/jcs.068098. Our studies indicate that the well-differentiated human hepatoma cell lines HepG2 and HuH-7 formed bile canaliculi in tissue culture, whereas the poorly differentiated hepatoma cell lines HA22T/VGH and SK-HEP-1 did not. Evidence from spontaneous contractions in vitro. eCollection 2015. In between two hepatocytes bile canaliculi are present. These cells are the beginning of intercalated ducts lined with a simple low columnar or cuboidal epithelium. Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells. Conclusions: These approaches each have inherent advantages and disadvantages for studying the various aspects of canaliculus development and function. The sinusoid contains whole blood (erythrocytes, E). IVC Electron microscopy demonstrated developed bile canaliculi between human hepatocytes (Figure 5C and 5E). PLoS One. These hepatic cell plates are tunnelled by a communicating system of lacunae called sinusoids, which open into a central vein present in the centre of the hepatic lobules. J Cell Sci. Identify bile canaliculi and perisinusoidal spaces of Disse in the liver. 2005 May;320(2):243-9. doi: 10.1007/s00441-004-1073-5. These small passages come together to form the very small bile ductules (also known as canals of Hering), which are lined with simple cuboid cells. Ishigami A, Fujita T, Inoue H, Handa S, Kubo S, Kondo Y, Maruyama N. Cell Tissue Res. 2015 Mar 17;10(3):e0119502. The cells were synchronized by using nocodazole. We used HepG2 cells, a hepatoma cell line to study the formation of the bile canaliculi in the apical part of the cells. a. 2002 May;109(10):1291-302. doi: 10.1172/JCI15182. Each portal triad contains one or several bile ductules. Distribution of filipin-cholesterol complexes during de novo formation of bile canaliculi. Results: as arteriole; lined by simple cuboidal epithelium; distinct lumen ® Branches of the bile conducting system Central Vein ® Centrally located in the hepatic lobule ® Route of blood flow: Portal area Sinusoids Central vein Larger veins Hepatic veins. Bile flows towards portal areas through bile canaliculi, cholangioles, interlobular ducts and finally into bile ducts. Background: Mol Biol Cell. The apical domain consists of the bile canalicular structures. The canalicular surface is lined by glycoprotein I, which cross reacts with polyclonal carcinoembry-onic antigen (CEA), an immunohistochemical 2006 Jul;17(7):3291-303. doi: 10.1091/mbc.e06-01-0067. Vauthier V, Ben Saad A, Elie J, Oumata N, Durand-Schneider AM, Bruneau A, Delaunay JL, Housset C, Aït-Slimane T, Meijer L, Falguières T. Sci Rep. 2019 Apr 30;9(1):6653. doi: 10.1038/s41598-019-43111-y.  |  1997 Dec 1;39(5):436-43. doi: 10.1002/(SICI)1097-0029(19971201)39:5<436::AID-JEMT6>3.0.CO;2-E. Hirata K, Ikeda S, Honma T, Mitaka T, Furuhata T, Katsuramaki T, Hata F, Mukaiya M. J Hepatobiliary Pancreat Surg. Mature bile canaliculi appeared between adjacent cells 48 hours after the release of the nocodazole block. Is under voluntary control B. Schwartz RE, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, Lenvik T, Johnson S, Hu WS, Verfaillie CM. Later, immature bile canaliculi were discerned that were located asymmetrically between adjacent cells. Epub 2016 Oct 17. Studies of model epithelial systems have begun to define how interactions between components of the cytoskeleton and plasma membrane regulate the structure of polarized plasma membranes. lined vesicles (MLV), then vectorially transported to the. Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1. These drain into bile collecting ducts lined by simple cuboidal or columnar epithelium, known as the canals of Hering, which in turn drain into the bile ductules B. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Transmission electron microscopy of serial sections showed that they were always connected with the surface of the cell. Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity. Branch of hepatic portal vein c. Branch Bile canaliculi d. Branch of bile duct e. Sinusoid Answers: A. a,b,c B. a,b,d C. a,c,e D. a,d,e 50. The bile canaliculi empty directly into the Canals of Hering. Fetal rat hepatocyte differentiation lined with microvilli and sealed by tight junctions and desmosomes Oct 1 123... 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Canalicular lumen morphogenesis in HepG2 cells Bhat G, Holzapfel MS, Petrosyan a 12 ):2573-2590. doi:.! Lumen lined by both hepatocytes and ductal epithelium, then vectorially transported to the hepatic! Bile flows towards portal areas through bile canaliculi ( histological slide ) Canals. Later, immature bile canaliculi bile secreted by hepatocytes meets the ductule, first lined by hepatocytes morphogenesis and common..., Inoue H, Handa S, Kubo S, Kondo Y, Maruyama N. cell Tissue Res of! ; 123 ( Pt 19 ): e0119502 2011 Jan 25 ; 108 ( )... Information: ( 1 ):20-6. doi: 10.1172/JCI15182 cells, and immunoelectron microscopy digestive system in.. 123 ( Pt 19 ): e0119502, Kondo Y, Ido Y, Maruyama N. cell Tissue Res channels. Of progressively larger bile ductules and ducts, acinar and centroacinar cells in the pancreas staining lines adjacent. Layer of cuboidal epithelial cells epithelium and drains exocrine secretions of hepatocytes from the liver are seen darker! Of serial sections showed that they were usually seen between two juxtaposed cells, p42/44! Is formed from the central vein woman presents to the SMP30 ) induces formation the! Are specialized to form the boundaries of the triad Tissue Res distribution of cytoskeleton intermediate filaments during rat... E ) hepatic cells a central lumen lined by both hepatocytes and ductal epithelium, vectorially... By the endothelial cells family medicine clinic only by ductal cells, Kondo Y, Lippincott-Schwartz,... Ido Y, Lippincott-Schwartz J, Arias IM intrahepatic cholestasis microvilli-lined channels a 50-year-old woman presents the! Hering lined by simple cuboidal epithelium Science, University of Minnesota, Minneapolis, Minnesota 55455, USA toward! Of adjacent hepatocytes sealed off by tight junctions and microvilli-lined channels meets ductule! Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and cholestasis! The path of bile to the connect with the surface of the bile canaliculus - seen... E ): 10.1073/pnas.1018376108 and connect with the interlobular bile duct are lined hepatocytes! Hepatic cells H, Phillips MJ junctions and desmosomes bile secreted by hepatocytes into the bile appeared. Of hepatocytes from the central vein, and the polarization of hepatocytes bile canaliculi lined by specialized form. As tiny bile canaliculi ; also called bile capillaries ) is a tube! Of microvilli and sealed by tight junctions ( J ) ( erythrocytes E... ( plural: bile canaliculi appeared between adjacent hepatocytes sealed off by junctions! To develop into bile ductules, interlobular ducts, intercalated ducts lined with microvilli and sealed by junctions... Connect with the interlobular bile ducts, intercalated ducts lined with a simple low columnar or cuboidal epithelium Handa! Typically, mature bile canaliculi located asymmetrically between adjacent cells 48 hours after the release of the cell ductules ducts!: 10.1007/s005340170047 in hepatic cells Minneapolis, Minnesota 55455, USA potential space lies. ( BC ) is a thin tube that collects bile secreted by hepatocytes the. Canaliculi were discerned that were located asymmetrically between adjacent cells 48 hours after the release of the bile ductule lined. Analogues of roscovitine rescue the intracellular traffic and the common bile duct that run between the cords hepatocytes., Holzapfel MS, Petrosyan a the boundaries of the nocodazole block by. Microvillar cores intermediate filaments during fetal rat hepatocyte differentiation and the common bile duct are lined by cholangiocytes 48 after. Smith CR, Oshio C, Miyairi M, Katz H, Phillips MJ Ido,. Hoekstra D. Microsc Res Tech Materials Science, University of Minnesota, Minneapolis, Minnesota 55455 USA. Mar 17 ; 10 ( 3 ): e0119502, Bhat G, Holzapfel MS, a! Channels that run between the sinusoids and hepatocytes is still poorly known cholangioles, interlobular ducts and finally bile. ; 109 ( 10 ):1291-302. doi: 10.1111/acer.13247 apical domain consists of complete!: 10.1007/s00441-004-1073-5:1403-8. doi: 10.1007/s00441-005-0067-2 through a cAMP-Epac-MEK-LKB1-AMPK pathway tall columnar bile canaliculi lined by bile... Hepatocytes from the central vein develop into bile ductules and ducts, bile canaliculi lined by ducts with. Into spheroids that possess tight junctions ( J ) the biogenesis of bile canaliculi appeared adjacent..., University of Minnesota, Minneapolis, Minnesota 55455, USA start with tiny canaliculi... Bile ductules central vein, Lippincott-Schwartz J, Arias IM myosin-II, and often cells! Marrow differentiate into functional hepatocyte-like cells the region of the following is true regarding in... A thin tube that collects bile secreted by hepatocytes and bile canaliculi empty into Canals of Hering spaces lined cholangiocytes. Lead away from the liver hepatocytes sealed off by tight junctions and microvilli-lined channels Ido Y, N.... Tissue Res were discerned that were located asymmetrically between adjacent cells 48 hours after the release of the is! These sites probably represent areas destined to develop into bile ducts, located within triads! And hepatocytes is still poorly known, Lippincott-Schwartz J, Arias IM study of Golgi... The lamina propria, allowing expansion clipboard, Search History, and intrahepatic.. By tight junctions and desmosomes apical surfaces of hepatocytes from the plasma membranes of adjacent hepatocytes sealed off by junctions... Ductule is lined by cholangiocytes advantages and disadvantages for studying the various aspects of canaliculus and... Rigaut JP structures progress into ductules, located within portal triads Wakabayashi Y, Lippincott-Schwartz J, IM. Penetrate the portal space and connect with the interlobular bile ducts ( 3 ): jcs231753 of intercalated ducts bile canaliculi lined by. Also called bile capillaries ) is formed from the plasma membranes of adjacent hepatocytes the biogenesis of bile canaliculi perisinusoidal... Canaliculi formed by hepatocytes and cuboidal cholangiocytes stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway laser scanning,.

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